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Fig. 8 | Cellular & Molecular Biology Letters

Fig. 8

From: Mitochondrial (mt)DNA–cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis

Fig. 8

The mechanism diagram shows that IRF7 and IRF3 can serve as intermediate signals for STING and NLRP3, linking the mtDNA–cGAS–STING axis and NLRP3–pyrotosis axis to further explain the molecular mechanism by which STING regulates the activation of NLRP3 inflammasomes. Inhibiting multiple molecules from mtDNA to NLRP3 can reduce macrophage pyroptosis and improve SAP-ALI

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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