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Fig. 6 | Cellular & Molecular Biology Letters

Fig. 6

From: Mitochondrial (mt)DNA–cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis

Fig. 6

Activation of STING can aggravate pyroptosis by up-regulating IRF7 and P-IRF3. A–D Ana-1 cells were transfected with 10 ug/ml 2′,3′-cGAMP or 5 ug/mL poly(dA:dT) for 6 h before stimulation with LPS and nigericin sodium salt. Western blot of STING, P-STING, IRF7, IRF3, P-IRF3, and NLRP3 (A, B). Pyroptosis of Ana-1 cells was measured by flow cytometry (C, D)

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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