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Table 1 The functional roles of CELF1 in cancer

From: Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review

Genes

Pathways/binding site

Target genes

Functions

Refs.

CELF1

3 ‘UTR GREs

DEK

Stabilize DEKmRNA and amplify carcinogenic signaling

[64]

Untranslated and overexpressed regions

CDKN1B

Inhibit the expression of CDKN1B and promote the proliferation of cancer cells

[69]

ERBB2/MAPK/P13K

AKT/ERK

Promote the proliferation of cancer cells

 

mRNA 3 ‘UTR

ETS2

Promote the proliferation、metastasis and invasion of cancer cells

[73]

mRNA 3 ‘UTR

BAX/BAD/JunD

Inhibit the expression of BAX/BAD/JunD and promote the proliferation of cancer cells

[76]

C/EBPa

C/EBPa

Inhibit the expression of C/EBPa and promote the proliferation of cancer cells

[78,79,80,81]

INSR shear

IR-A

Promote IR-A expression, and influences carcinogenic signaling through the insulin-signaling pathway of breast cancer

[87]

MiR-330-3p

mRNA 3 ‘UTR

CELF1

Down-regulating the expression of CELF1 inhibited the proliferation and migration of glioma cells

[68]

BACE1-AS

miR-377-3p

miR-377-p/CELF1 axis

Promoting the invasion and metastasis of liver cancer cells

[92]

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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