Fig. 8

PFN2 was the downstream targets for miR-1287-5p. A Volcano plot showing the different expression mRNA. B Bioinformatics and mRNA sequencing detection showing the downstream target of miR-1287-5p. C Prediction of binding sites of miR-1287-5p and 3′-UTR of PFN2. The MUT version of 3′-UTR of PFN2 is presented. D Relative luciferase activity determined 48 h after transfection of H1833 cells with miR-1287-5p mimic/NC or 3′-UTR of PFN2 WT/Mut. Data presented as mean ± SD. ***P < 0.001