Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content
Fig. 1 | Cellular & Molecular Biology Letters

Fig. 1

From: Role of microRNA-4739 in enhancing cisplatin chemosensitivity by negative regulation of RHBDD2 in human cervical cancer cells

Fig. 1

The dysregulation of miR-4739 and RHBDD2 were associated with the DDP resistance of CC. A, B Parental CC cell lines (HeLa and SiHa) and their corresponding DDP-resistant cell lines (HeLa/DDP and SiHa/DDP) were exposed to 1, 2, 3, 4, 5 μg/ml DDP and the cell viability was determined using CCK-8 assay. C IC50 values of HeLa, HeLa/DDP, SiHa and SiHa/DDP cells were calculated and shown. D The miR-4739 expression levels in HeLa, HeLa/DDP, SiHa and SiHa/DDP cells were determined using quantitative real time PCR. E The protein levels of RHBDD2, P-gP, and MRP1 were detected via western blot analysis in HeLa, HeLa/DDP, SiHa, and SiHa/DDP cells. F MiR-4739 expression in DDP-sensitive and DDP-resistant CC tissues both from patients with CC (n = 35) was determined using quantitative real-time PCR. *p < 0.05, **p < 0.01, ***p < 0.001, compared with HeLa or SiHa via Student’s t-test

Back to article page

Cellular & Molecular Biology Letters

ISSN: 1689-1392

Contact us