Role of N6-methyladenosine methylation in glioma: recent insights and future directions

Table 1 The function of m6A methylation regulators in the central nervous system

Regulators	Roles in nervous system regulation	Related targets	References
METTL3	↑Proliferation of NSCs	↑Ezh2	[27]
	↑Cortical neurogenesis		[29]
	↑Cerebellar development	↓Atoh1, Cxcr4, Notch2	[35]
	↑Long-term memory formation	↑IEGs	[36]
METTL14	↑Proliferation of NSCs	↓CBP, p300	[28]
	↓Premature differentiation of NSCs	↓CBP, p300	[28]
	↑Cortical neurogenesis		[30]
	↑Acquisition of response learning and reversal learning	↑striatal mRNAs encoding neuron- and synapse-specific protein	[37]
	↑Axon regeneration	↑De novo gene	[44]
FTO	↑Proliferation and neuronal differentiation of aNSCs	↑PDGFRA/SOCS5-STAT3	[32]
	↓Neuronal apoptosis	↑BDNF	[33]
	↓Synaptic plasticity	↓ADRB2 / c-MYC / SIRT1	[39]
	↑Neuronal signaling	↑DA signaling pathway	[41]
	↑Hippocampal neurogenesis and cellular differentiation	↓HPA axis	[42]
	↑Axon elongation	↑GAP-43	[43]
ALKBH5	↑Cerebellar development	↓Mphosph9	[34]
YTHDF1	↑long-term synaptic plasticity	↑GRIN1, GRIN2A, GRIA1, CAMK2A, CAMK2B	[38]
YTHDF1	↑axon regeneration	↑De novo gene	[44]

ISSN: 1689-1392