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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression

Fig. 2

dCas9-KRAB gene expression in prostate cancer cells. A RNA expression levels of dCas9-KRAB in four prostate cancer cell lines and one prostate cell line. B RNA expression levels of PSA mRNA in four prostate cancer cell lines and one prostate cell line. C dCas9-KRAB/sgRNA targeting the PSA ORF region locally forms heterochromatin and blocks the sliding of RNA polymerase on the DNA strand. **P < 0.01 (Student’s t-test, n = 3 replicates)

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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