Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.

Skip to main content
Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice

Fig. 4

CEBPB induces the transcription of BZW1. A Venn diagram of the regulatory downstream targets of CEBPB downloaded from the hTFtarget database and the differentially expressed genes in the GSE157293 and GSE153547 datasets. B Analysis of single-cell expression of BZW1 in the kidney by the Human Protein Atlas database. C BZW1 expression in kidney tissues of patients with LN (n = 23) was analyzed using RT–qPCR. D Correlation between BZW1 and CEBPB expression in kidney tissues of patients with LN (n = 23). E BZW1 expression in kidney tissues of mice was examined using RT–qPCR. F BZW1 was predicted as a downstream transcriptional regulatory target of CEBPB using hTFtarget. G CEBPB binding sites on BZW1 promoter predicted using the Jaspar database. H The binding relation between CEBPB and BZW1 promoter using ChIP–qPCR. I CEBPB and BZW1 expression in BMDM with knockdown of CEBPB by RT–qPCR. J The transcriptional regulation between CEBPB and BZW1 by dual-luciferase reporter assay. Data are presented as means ± SD and representative of three independent experiments (n = 8, *p < 0.05). Data were statistically analyzed using an unpaired t-test (C, H), one-way ANOVA (E, J), or two-way ANOVA (I)

Back to article page