Fig. 5

The schematic diagram of GZMA in osteoclasts. GZMA degrades exportin 5 that transports miR-25-3p pre-miRNA from the nucleus to the cytoplasm of osteoclast, and suppresses the expression of miR-25-3p. TGF-β promotes the expression of PAR1 and finally facilitates cell growth, inhibited cell apoptosis in osteoclasts