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Fig. 6 | Cellular & Molecular Biology Letters

Fig. 6

From: Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs)

Fig. 6

ESCC exosome circ_0026611 interacted with NAA10 to inhibit the acetylation and ubiquitination of PROX1 in HLECs. A NAA10 enrichment as well as its protein expression in HLECs. B NAA10 expression as well as protein expression affected by circ_0026611. C Protein expression of PROX1 in different conditions. D The effect of circ_0026611 on the interaction between NAA10 and PROX1 was assessed by CoIP. E The expression of NAA10 and PROX1 protein in HLECs under different treatments. F Western blot assay was conducted to test the effect of different EC109-Exos treatments on PROX1 protein. G CoIP assay was used to determine the effect of circ_0026611 on PROX1 protein acetylation and ubiquitination. H CoIP was carried out to assess the effect of EC109-Exos coated with different circ_0026611 expression levels on PROX1 protein. **P < 0.01

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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