Table 6 Role of CDKN2B-AS1 in microRNA sponging in cancer.
Cancer site | Sponged microRNA | Genes/pathway | Putative function | PubMed ID |
|---|---|---|---|---|
Breast (TNBC) | miR-199a | Proliferation and apoptosis | 28961506 | |
Cervical cancer | miR-186 | Cancer development | 28550682 | |
Oral cancer | miR-125a | Cell proliferation, migration, and invasion | 29635126 | |
Hepatocellular carcinoma | miR-122-5p | Cell proliferation, invasion, and metastasis | 29127494 | |
miR-153-5p | ARHGAP18 | Metastasis | 30510148 | |
miR-384 | STAT3 | 31679275 | ||
miR-191 | NF-κB and Wnt/β-catenin | Apoptosis, proliferation, metastasis, and invasion | 30249208 | |
let-7c-5p | NAP1L1 | 30165194 | ||
miR-122-5p | Cell proliferation, metastasis, and invasion | 29127494 | ||
Gastric cancer | miR-99a | BMI1, Bcl-2 | Cancer development | 30156609 |
Colorectal | let-7a | ATP-binding cassette subfamily C member 1 | 30279206 | |
Prostate cancer | let-7a | TGF-β1/Smad | Proliferation and migration | 29278879 |
Glioma | miR-34a | Sirt1, PI3K/AKT, and mTOR | Cell proliferation, migration, and invasion | 29057547 |
Retinoblastoma | miR-99a | c-MYC | Apoptosis, proliferation, metastasis and invasion | 31184221 |
miR-24 | c-MYC, MEK/ERK, and Wnt/β-catenin | Viability, migration, and invasion | 30703428 | |
Osteosarcoma | miR-125a-5p | STAT3 | Cisplatin chemoresistance | 30777616 |
Nasopharyngeal carcinoma | miR-125a | 28402230 | ||
let-7a | Cisplatin chemoresistance | 28117929 | ||
Medulloblastoma | miR-323 | BRI3 and CDK6, p38 MAPK, ERK, and AKT, Wnt signaling | Cell proliferation and migration through miR-323-mediated regulation of BRI3 | 28513871 |