Fig. 2
From: Enhancer RNAs: transcriptional regulators and workmates of NamiRNAs in myogenesis
Biogenesis of NamiRNAs in the nucleus and cytoplasm. Pol II transcribes miRNA coding genes in the same loci as enhancers. MPC process the ds-miRNA into hairpin loop structures. Nuclear AGO2 and RNAi factors Dicer and TRBP process ds-miRNA into NamiRNAs in the nucleus. Alternatively, cytoplasmic produced miRNAs which were transcribed from genes with enhancer associated properties are activated by a RISC-like structure in the cytoplasm. The activated NamiRNAs in the cytoplasm are transported back into the nucleus via FXR1 to perform their activation and enhancing function