Fig. 2

Diacerein ameliorated kidney injury in endotoxemic mice. a and b Mice were injected intraperitoneally with lipopolysaccharide (LPS, 10 mg/kg) for 24 h, and then treated with diacerein (15 mg/kg/day) for a further 48 h. Histological analysis of representative renal cortex (a) and medulla (b) slides of control, LPS, LPS + DMSO and LPS + Diacerein groups. n = 8 in each group (magnification, 100×). Arrows indicate pathologic changes, such as glomerular congestion and atrophy, interstitial hemorrhages, and epithelial cell necrosis and shedding in cortex, and erythrocyte extravasation, cast formation, tubular collapse and collecting duct necrosis in medulla. Diacerein treatment attenuated renal damage induced by endotoxemia