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Table 1 Norpurpureine prevents ADP-induced platelet adhesion onto fixed fibrinogen

From: The norpurpureine alkaloid from Annona purpurea inhibits human platelet activation in vitro

 

Net Adhesion (AU)

Platelet-specific adhesion (PSA) to Fg induced by ADP

PSA (%) vs. vehicle

ADP (−)

ADP (+)

Vehicle

0.39 (0.04)

0.95 (0.05)

0.56 (0.05)

100.00 (4.7)

Norp 220 μM

0.42 (0.03)

0.51 (0.04)

0.09 (0.01)

16.07 (1.8)***

Norp 90 μM

0.41 (0.02)

0.73 (0.04)

0.32 (0.02)

56.55 (3.7)***

Norp 30 μM

0.42 (0.03)

0.85 (0.02)

0.43 (0.03)

76.78 (4.7)**

Apyrase

0.40 (0.02)

0.49 (0.03)

0.09 (0.02)

16.67 (2.7)***

  1. Platelets in PRP (1 × 105) were pretreated with vehicle (DMSO 0.25%), apyrase (0.5 U/ml) or norpurpureine (Norp) at the indicated concentrations for 10 min before the addition of 10 μM ADP to test their adhesion onto fixed fibrinogen (Fg). The values are the means ± SD (n = 3, done in triplicate) p < 0.01 (**) and p < 0.001 (***) compare to vehicle.
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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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